SQLite DB access using clickonce generated shortcut

I'm using a SQLite DB in my program, and it runs without issue in VS or looking in my debug folder. I then deploy a clickonce application and after installing it fails to access the database, the exact error I'm getting is:



Now if I go into where the clickonce application is installed and run the program from that folder it runs without issue, I only get the problem when using the shortcut generated by the clickonce application.

Anyone have any thoughts on why? Thanks in advance for any insight.